Joe Rogan believes that Will Smith made a huge mistake on the night when Jada Pinkett Smith introduced him to Tupac Shakur. He thinks that if the two hadn't crossed paths that night, their lives would have turned out differently. Rogan believes that Smith would have been a superstar if he hadn't been distracted by his friendship with Tupac. Additionally, he suggests that this distraction caused Smith to miss out on potential career opportunities. Overall, Rogan seems to believe that Smith's encounter with Tupac was a pivotal moment in his life that he deeply regrets.